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CALCIUMFOLINAT EBEWE

Package(a):
VIAL: 1 x 200 mg/20 ml.
Dosage(a):
I.V. and I.M. use only. In case of I.V. use, no more than 160 mg of calcium folinate should be injected per minute due to calcium content. For I.V. infusion, calcium folinate may be diluted with 0.9% sodium chloride solution or 5% glucose solution before use. See prescribing information for full details.
Prescribing Restrictions:  None

Package(b):
VIAL: 1 x 800 mg/80 ml.
Dosage(b):
I.V. and I.M. use only. In case of I.V. use, no more than 160 mg of calcium folinate should be injected per minute due to calcium content. For I.V. infusion, calcium folinate may be diluted with 0.9% sodium chloride solution or 5% glucose solution before use. See prescribing information for full details.
Prescribing Restrictions:  None


Indications:
Diminish the toxicity and counteract the action of palliative treatment of the folic antagonists in cytotoxic therapy. As calcium folinate ?luorouracil chemotherapy combination for cancer treatment.
Contra-Indications:
Hypersensitivity to calcium folinate. Pernicious anemia or other anemia due to vitamin B₁₂ deficiency.
Special Precautions:
Pregnancy and lactation. See prescribing information for full details.
Side Effects:
Insomnia, agitation and depression after high doses have been reported. See prescribing information for full details.
Drug Interactions:
See prescribing information for full details.