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HYCAMTIN

Package(a):
VIAL (for infusion): 1.
Dosage(a):
1.5 mg/m²/day for 5 days every 21 days.
Prescribing Restrictions:    

Package(b):
VIALS (for infusion): 5.
This package has been discontinued.
Dosage(b):
1.5 mg/m²/day 5 days every 21 days.
Prescribing Restrictions:  None


Indications:
Small cell lung cancer sensitive disease after failure of first line chemotherapy. Metastatic carcinoma of the ovary after failure of first-line or subsequent therapy. In combination with cisplatin for the treatment of stage IV-B, recurrent, or persistent carcinoma of the cervix, which is not amenable to curative treatment with surgery and/or radiation therapy.
Contra-Indications:
History of severe hypersensitivity reactions to topotecan and/or its excipients. Pregnancy and lactation. Present severe bone marrow depression prior to starting first course.
Special Precautions:
Should be administered under the direction of a physician experienced in the use of cytotoxic agents. Should not be used as a single agent therapy in first line patients. Full blood count including platelets should be monitored regularly. Dose adjustment may be necessary if administered in combination with other cytotoxic agents. See prescribing information for full details.
Side Effects:
Infection, sepsis. Anemia, febrile neutropenia, leucopenia, neutropenia, thrombocytopenia. Hypersensitivity, including rash. Anorexia (may be severe). Diarrhea, nausea and vomiting (all of which may be severe), abdominal pain, constipation and stomatitis. Hyperbilirubinemia, alopecia, asthenia, fatigue, pyrexia, malaise. See prescribing information for full details.
Drug Interactions:
N/A